SCHEMBL7469012

SCHEMBL7469012

CCOC(=O)c1scc(Cl)c1OS(=O)(=O)Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.41
TP53 P04637 3/20 0.41
HTT P42858 2/20 0.40
POLB P06746 2/20 0.39
ALDH1A1 P00352 4/20 0.39
MAPK1 P28482 2/20 0.39
KDM4E B2RXH2 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
LMNA P02545 2/20 0.38
THRB P10828 1/20 0.38
HSD17B10 Q99714 2/20 0.37
NPC1 O15118 1/20 0.37
XBP1 P17861 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
TLR9 Q9NR96 1/20 0.37
GAA P10253 1/20 0.37
KMT2A Q03164 1/20 0.37
GLP1R P43220 1/20 0.36
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7474149 0.89 STS (0.38) MAPTTP53HTTPOLBALDH1A1
SCHEMBL7466240 0.87 MAPT (0.39) MAPTTP53POLBALDH1A1LMNA
SCHEMBL7470040 0.86 ALDH1A1 (0.41) MAPTTP53HTTPOLBALDH1A1
SCHEMBL7472780 0.86 MAPT (0.39) MAPTTP53HTTPOLBALDH1A1
SCHEMBL7470407 0.84 MAPT (0.45) MAPTTP53ALDH1A1MAPK1KDM4E
SCHEMBL7469821 0.84 KDM4E (0.42) MAPTTP53POLBKDM4ELMNA
SCHEMBL7463597 0.83 MAPT (0.44) MAPTTP53POLBALDH1A1KDM4E
SCHEMBL7477592 0.82 LMNA (0.37) MAPTTP53POLBALDH1A1MAPK1
SCHEMBL7475408 0.81 MAPK8 (0.40) MAPTTP53POLBALDH1A1KDM4E
SCHEMBL7471026 0.80 COMT (0.34) POLBALDH1A1KDM4ELMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0859774-B1 SUBSTITUTED SULPHONYLAMINO (THIO)CARBONYL COMPOUNDS AS HERBICIDES BAYER AG (DE) 2002-04-03 EP disclosed
EP-0859774-A1 SUBSTITUTED SULPHONYLAMINO (THIO)CARBONYL COMPOUNDS AS HERBICIDES BAYER AG (DE) 1998-08-26 EP disclosed
WO-1997016449-A1 SUBSTITUTED SULPHONYLAMINO (THIO)CARBONYL COMPOUNDS AS HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-05-09 WO disclosed