Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410219 | 0.89 | LMNA (0.49) | LMNAL3MBTL1ALDH1A1MAPTKDM4E | |
| SCHEMBL8621598 | 0.86 | LMNA (0.47) | LMNAL3MBTL1ALDH1A1MAPTKDM4E | |
| SCHEMBL7410235 | 0.81 | LMNA (0.44) | LMNAL3MBTL1ALDH1A1MAPTKDM4E | |
| SCHEMBL7411523 | 0.80 | OXER1 (0.44) | LMNAL3MBTL1ALDH1A1MAPTKDM4E | |
| SCHEMBL7412570 | 0.78 | LMNA (0.48) | LMNAL3MBTL1ALDH1A1MAPTKDM4E | |
| SCHEMBL7422800 | 0.74 | KMT2A (0.58) | L3MBTL1ALDH1A1KDM4EHPGDHTT | |
| SCHEMBL7470065 | 0.74 | MEN1 (0.68) | L3MBTL1ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL7407743 | 0.73 | NR4A2 (0.44) | LMNAL3MBTL1ALDH1A1MAPTKDM4E | |
| SCHEMBL7707705 | 0.73 | SMN1; SMN2 (0.42) | LMNAL3MBTL1ALDH1A1MAPTKDM4E | |
| SCHEMBL7707708 | 0.70 | KMT2A (0.41) | LMNAL3MBTL1ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |