Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | PGK1 | P00558 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GALR3 | O60755 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472816 | 0.87 | EGFR (0.48) | EGFRPGK1MAPK1HTTRAF1 | |
| SCHEMBL7473897 | 0.82 | EGFR (0.55) | EGFRMAPK1HTT | |
| SCHEMBL7467576 | 0.81 | EGFR (0.39) | EGFRHTTLMNAKMT2ASMN1; SMN2 | |
| SCHEMBL7465009 | 0.80 | HTT (0.57) | EGFRPGK1MAPK1HTTLMNA | |
| SCHEMBL7475194 | 0.80 | EGFR (0.66) | EGFRMAPK1HTTLMNAGALR3 | |
| SCHEMBL7473179 | 0.80 | MAPK1 (0.58) | EGFRMAPK1HTTLMNAL3MBTL1 | |
| SCHEMBL7472725 | 0.79 | EGFR (0.61) | EGFRAURKARPS6KB1MAPK1HTT | |
| SCHEMBL7470701 | 0.79 | PDE5A (0.56) | EGFRMAPK1HTTRAF1LMNA | |
| SCHEMBL7461665 | 0.78 | USP10 (0.59) | EGFRMAPK1HTTLMNAMEN1 | |
| SCHEMBL7474668 | 0.78 | HTT (0.63) | EGFRMAPK1HTTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |