Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.48 |
| ▸ | PGK1 | P00558 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470464 | 0.87 | EGFR (0.46) | EGFRPGK1MAPK1HTTRAF1 | |
| SCHEMBL7473897 | 0.85 | EGFR (0.55) | EGFRMAPK1HTT | |
| SCHEMBL7465009 | 0.85 | HTT (0.57) | EGFRPGK1MAPK1HTTKDM4E | |
| SCHEMBL7475194 | 0.82 | EGFR (0.66) | EGFRMAPK1HTTKDM4E | |
| SCHEMBL7473179 | 0.82 | MAPK1 (0.58) | EGFRMAPK1HTT | |
| SCHEMBL7472725 | 0.81 | EGFR (0.61) | EGFRMAPK1HTT | |
| SCHEMBL7470701 | 0.81 | PDE5A (0.56) | EGFRMAPK1HTTKDM4EALDH1A1 | |
| SCHEMBL7474842 | 0.81 | RXFP1 (0.62) | EGFRPGK1MAPK1HTTKDM4E | |
| SCHEMBL7461665 | 0.81 | USP10 (0.59) | EGFRMAPK1HTT | |
| SCHEMBL7474668 | 0.80 | HTT (0.63) | EGFRMAPK1HTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |