Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.50 |
| ▸ | MERTK | Q12866 | 2/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473179 | 0.88 | MAPK1 (0.58) | EGFRMAPK1LMNA | |
| SCHEMBL7472725 | 0.87 | EGFR (0.61) | EGFRMAPK1 | |
| SCHEMBL7461665 | 0.86 | USP10 (0.59) | EGFRMAPK1LMNA | |
| SCHEMBL7465009 | 0.86 | HTT (0.57) | EGFRMAPK1ALDH1A1LMNA | |
| SCHEMBL7473897 | 0.86 | EGFR (0.55) | EGFRMAPK1 | |
| SCHEMBL7475194 | 0.86 | EGFR (0.66) | EGFRMAPK1LMNATSHR | |
| SCHEMBL7474668 | 0.83 | HTT (0.63) | EGFRPDE5AMAPK1ALDH1A1LMNA | |
| SCHEMBL7469854 | 0.83 | EGFR (0.56) | EGFRMAPK1LMNA | |
| SCHEMBL7460787 | 0.82 | EGFR (0.51) | EGFRMAPK1 | |
| SCHEMBL7475448 | 0.82 | EGFR (0.56) | EGFRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |