Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 6/20 | 0.41 |
| ▸ | PPARA | Q07869 | 6/20 | 0.41 |
| ▸ | PPARD | Q03181 | 5/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474367 | 0.85 | MAOA (0.43) | TSHRALDH1A1KDM4EBCL2MCL1 | |
| SCHEMBL7477071 | 0.85 | THRA (0.52) | TDP1KDM4EBCL2MCL1PPARG | |
| SCHEMBL7477074 | 0.83 | FLT1 (0.41) | TSHRALDH1A1KDM4EPPARGPPARA | |
| SCHEMBL7473999 | 0.82 | PPARG (0.49) | TSHRBCL2MCL1PPARG | |
| SCHEMBL7477507 | 0.82 | CA12 (0.46) | TSHRALDH1A1KDM4EBCL2MCL1 | |
| SCHEMBL27583598 | 0.81 | PPARG (0.42) | TSHRPPARGPPARAPPARDFLT1 | |
| SCHEMBL27583585 | 0.81 | LMNA (0.47) | TSHRALDH1A1KDM4ESMN1; SMN2FLT1 | |
| SCHEMBL7481379 | 0.81 | ALDH1A1 (0.46) | TSHRALDH1A1KDM4ESMN1; SMN2FLT1 | |
| SCHEMBL7482851 | 0.79 | PPARG (0.51) | PPARG | |
| SCHEMBL7478282 | 0.78 | TSHR (0.42) | TSHRALDH1A1MAPK1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210343-A2 | BENZOIC ACID DERIVATIVES AND THEIR USE AS PPAR RECEPTOR AGONISTS | AstraZeneca AB (SE) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001012187-A2 | BENZOIC ACID DERIVATIVES AND THEIR USE AS PPAR RECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2001-02-22 | — | — | WO | disclosed |