Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.51 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7483118 | 0.88 | NR1H4 (0.44) | LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL7482004 | 0.83 | ALDH1A1 (0.46) | LMNAALDH1A1GAAMAPTKDM4E | |
| SCHEMBL7472363 | 0.82 | L3MBTL1 (0.49) | ALDH1A1MAPTKDM4EHTTKMT2A | |
| SCHEMBL7471334 | 0.81 | SMN1; SMN2 (0.52) | KCNK3KAT6APOLBCTDSP1ALDH1A1 | |
| SCHEMBL7472887 | 0.81 | ALDH1A1 (0.48) | LMNAPOLBALDH1A1NPSR1GAA | |
| SCHEMBL7482260 | 0.81 | KCNA3 (0.48) | KCNK3ALDH1A1RXFP1MAPTKDM4E | |
| SCHEMBL7481028 | 0.81 | KMT2A (0.60) | ALDH1A1RXFP1MAPTKDM4EHTT | |
| SCHEMBL7476927 | 0.79 | HDAC8 (0.55) | LMNAKAT6AALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL7480996 | 0.78 | RAB9A (0.56) | KCNK3KAT6APOLBCTDSP1ALDH1A1 | |
| SCHEMBL7478056 | 0.78 | KMT2A (0.46) | LMNAKCNK3POLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | claimed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |