Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 8/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 5/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27976403 | 0.83 | HTT (0.39) | CYP3A4KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL27768567 | 0.75 | TSHR (0.34) | KMT2AMEN1ALDH1A1MAPTCYP1A2 | |
| SCHEMBL15057654 | 0.74 | MEN1 (0.35) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL8428534 | 0.70 | ABCB1 (0.36) | KMT2AMEN1ALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL10783455 | 0.68 | L3MBTL1 (0.32) | — | |
| SCHEMBL1847048 | 0.68 | PKM (0.37) | CYP3A4KMT2AALDH1A1CYP2C19TSHR | |
| SCHEMBL14992328 | 0.68 | ALDH1A1 (0.39) | CYP3A4KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL866591 | 0.67 | — | — | |
| SCHEMBL27674117 | 0.65 | TSHR (0.34) | KMT2AMEN1ALDH1A1MAPTHSD17B10 | |
| SCHEMBL6688749 | 0.64 | THRB (0.31) | ALDH1A1SMN1; SMN2TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |