Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.42 |
| ▸ | P4HB | P07237 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 3/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6299083 | 0.86 | MAOA (0.33) | P4HBCASP3 | |
| SCHEMBL57109 | 0.68 | KIF11 (0.84) | KIF11P4HBNQO2PTGS1PTGS2 | |
| SCHEMBL23635077 | 0.67 | POLB (0.42) | P4HBESR2ESR1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL29242575 | 0.66 | KIF11 (0.80) | KIF11P4HBNQO2PTGS1PTGS2 | |
| SCHEMBL28039722 | 0.66 | KIF11 (0.80) | KIF11P4HBNQO2PTGS1PTGS2 | |
| SCHEMBL27509291 | 0.66 | KIF11 (0.80) | KIF11P4HBNQO2PTGS1PTGS2 | |
| Hydrochloric Acid SCHEMBL18955872 | 0.66 | KIF11 (0.80) | KIF11P4HBNQO2PTGS1PTGS2 | |
| SCHEMBL11756670 | 0.66 | KIF11 (0.80) | KIF11P4HBNQO2PTGS1PTGS2 | |
| Potassium SCHEMBL30655561 | 0.66 | KIF11 (0.80) | KIF11P4HBNQO2PTGS1PTGS2 | |
| SCHEMBL7464656 | 0.64 | CES2 (0.36) | CASP3XDHSLC22A12ESR2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204659-A2 | SEROTONERGIC BENZOFURANS | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| EP-1204654-A1 | BENZOFURYLPIPERAZINES AND BENZOFURYLHOMOPIPERAZINES: SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009111-A1 | BENZOFURYLPIPERAZINES AND BENZOFURYLHOMOPIPERAZINES: SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |
| WO-2001009122-A2 | SEROTONERGIC BENZOFURANS | ELI LILLY AND COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |