Hydrochloric Acid

Hydrochloric Acid

SCHEMBL18955872

Cl.Oc1ccc(C(F)(F)F)cc1

nearest known ligand 0.80

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 known ✓ P03372 3/20 0.59
ESR2 known ✓ Q92731 3/20 0.59
PTGS1 known ✓ P23219 2/20 0.53
PTGS2 known ✓ P35354 1/20 0.53
SLC6A2 known ✓ P23975 1/20 0.50
SLC6A4 known ✓ P31645 1/20 0.50
HTR6 known ✓ P50406 1/20 0.50
SLC6A3 known ✓ Q01959 1/20 0.50
CA2 known ✓ P00918 1/20 0.47
KIF11 P52732 2/20 0.80
NQO2 P16083 1/20 0.53
LMNA P02545 3/20 0.50
TSHR P16473 2/20 0.50
TYR P14679 2/20 0.50
CYP3A4 P08684 2/20 0.50
HPGD P15428 2/20 0.50
HSD17B10 Q99714 2/20 0.50
CES2 O00748 1/20 0.50
CES1 P23141 1/20 0.50
ORAI1 Q96D31 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL29242575 1.00 KIF11 (0.80) KIF11ESR1ESR2PTGS1NQO2
SCHEMBL57109 0.97 KIF11 (0.84) KIF11ESR1ESR2PTGS1NQO2
SCHEMBL28039722 0.94 KIF11 (0.80) KIF11ESR1ESR2PTGS1NQO2
SCHEMBL27509291 0.94 KIF11 (0.80) KIF11ESR1ESR2PTGS1NQO2
SCHEMBL11756670 0.94 KIF11 (0.80) KIF11ESR1ESR2PTGS1NQO2
Potassium SCHEMBL30655561 0.94 KIF11 (0.80) KIF11ESR1ESR2PTGS1NQO2
SCHEMBL678508 0.89 KIF11 (1.00) KIF11ESR1ESR2PTGS1NQO2
SCHEMBL12675678 0.89 KIF11 (1.00) KIF11ESR1ESR2PTGS1NQO2
Cyclohexane SCHEMBL28939325 0.89 KIF11 (0.73) KIF11ESR1ESR2PTGS1NQO2
Phenol SCHEMBL28745379 0.87 KIF11 (0.70) KIF11ESR1ESR2PTGS1NQO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3386511-B2 METHODS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS INC (US) 2024-03-20 EP claimed
EP-4658649-A1 [1,2,4]TRIAZOLO[4,3-A]PYRIDINES AND [1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS NLRP3 INHIBITORS Janssen Pharmaceutica NV (BE) 2025-12-10 EP disclosed
WO-2024160694-A1 [1,2,4]TRIAZOLO[4,3-a]PYRIDINES AND [1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS NLRP3 INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2024-08-08 WO disclosed
WO-2023088856-A1 HETEROCYCLIC NLRP3 INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2023-05-25 WO disclosed
US-11638706-B2 Methods for treating Huntington's disease PTC THERAPEUTICS, INC. (US) 2023-05-02 US disclosed
US-11608501-B2 Methods for modifying RNA splicing PTC THERAPEUTICS, INC. (US) 2023-03-21 US disclosed
US-20220387428-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS AG (CH) 2022-12-08 US disclosed
US-11229648-B2 1,4-disubstituted pyridazine analogs thereof and methods for treating SMN-deficiency-related conditions NOVARTIS AG (CH) 2022-01-25 US disclosed
US-20210275526-A1 METHODS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS INC (US) 2021-09-09 US disclosed
US-10881658-B2 Methods for treating Huntington's disease PTC THERAPEUTICS, INC. (US) 2021-01-05 US disclosed
US-10874672-B2 Methods for treating Huntington's disease PTC THERAPEUTICS, INC. (US) 2020-12-29 US disclosed
US-20200370043-A1 METHODS FOR MODIFYING RNA SPLICING PTC THERAPEUTICS, INC. (US) 2020-11-26 US disclosed
US-20200345732-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. 2020-11-05 US disclosed
EP-3638318-A1 METHODS FOR MODIFYING RNA SPLICING PTC Therapeutics, Inc. (US) 2020-04-22 EP disclosed
US-20200113904-A1 METHODS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS INC (US) 2020-04-16 US disclosed
US-20190000844-A1 METHODS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS, INC. 2019-01-03 US disclosed
WO-2018232039-A1 METHODS FOR MODIFYING RNA SPLICING PTC THERAPEUTICS, INC. (US) 2018-12-20 WO disclosed
EP-3386511-A1 METHODS FOR TREATING HUNTINGTON'S DISEASE PTC Therapeutics, Inc. (US) 2018-10-17 EP disclosed
WO-2017100726-A1 METHODS FOR TREATNG HUNTINGTON'S DISEASE PTC THERAPEUTICS, INC. (US) 2017-06-15 WO disclosed
CN-102307861-A Phenylimidazole compounds OTSUKA PHARMA CO LTD (JP) 2012-01-04 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210275526-A1 METHODS FOR TREATING HUNTINGTON'S DISEASE HTT, HYPK, FH ESR1 4703/4885ESR2 3865/4885PTGS1 1721/4885
US-20190000844-A1 METHODS FOR TREATING HUNTINGTON'S DISEASE HTT, HYPK, FH ESR1 4703/4885ESR2 3865/4885PTGS1 1721/4885
US-20200370043-A1 METHODS FOR MODIFYING RNA SPLICING RBM17, SNRPE, SNRPA1 ESR1 2854/4885ESR2 1041/4885PTGS1 1881/4885
US-20200113904-A1 METHODS FOR TREATING HUNTINGTON'S DISEASE HTT, HYPK, FH ESR1 4703/4885ESR2 3865/4885PTGS1 1721/4885
US-11229648-B2 1,4-disubstituted pyridazine analogs thereof and methods for treating SMN-deficiency-related conditions SMN1; SMN2, SF3B5, CLN6 ESR1 4860/4885ESR2 4800/4885PTGS1 3048/4885
US-10881658-B2 Methods for treating Huntington's disease HTT, HYPK, FH ESR1 4703/4885ESR2 3865/4885PTGS1 1721/4885
US-10874672-B2 Methods for treating Huntington's disease HTT, HYPK, FH ESR1 4703/4885ESR2 3865/4885PTGS1 1721/4885
US-20200345732-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS SMN1; SMN2, CLN6, SF3B5 ESR1 4859/4885ESR2 4775/4885PTGS1 2190/4885
US-11608501-B2 Methods for modifying RNA splicing RBM17, SNRPA1, SNRPE ESR1 3390/4885ESR2 1397/4885PTGS1 1822/4885
US-20220387428-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS SMN1; SMN2, CLN6, SF3B5 ESR1 4859/4885ESR2 4775/4885PTGS1 2190/4885
US-11638706-B2 Methods for treating Huntington's disease HTT, HYPK, FH ESR1 4703/4885ESR2 3865/4885PTGS1 1721/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.