Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477635 | 0.80 | PPARG (0.52) | SERPINE1PPARGTSHR | |
| SCHEMBL7477006 | 0.79 | SERPINE1 (0.51) | SERPINE1PPARGHDAC2 | |
| SCHEMBL27583578 | 0.78 | SERPINE1 (0.41) | POLBSERPINE1PPARGBCL2MCL1 | |
| SCHEMBL7524721 | 0.77 | KMT2A (0.57) | POLBKDM4EALDH1A1HDAC2MEN1 | |
| SCHEMBL7475485 | 0.72 | MMP12 (0.42) | MMP12MMP13ALOX5KDM4EALDH1A1 | |
| SCHEMBL7247046 | 0.70 | CCR2 (0.61) | SERPINE1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7478024 | 0.70 | ALDH1A1 (0.52) | POLBSERPINE1PPARGKDM4EALDH1A1 | |
| SCHEMBL14233800 | 0.69 | PPARG (0.70) | PPARG | |
| SCHEMBL12394316 | 0.69 | HDAC2 (0.58) | POLBMMP12MMP13ALOX5KDM4E | |
| SCHEMBL7482851 | 0.69 | PPARG (0.51) | SERPINE1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210343-A2 | BENZOIC ACID DERIVATIVES AND THEIR USE AS PPAR RECEPTOR AGONISTS | AstraZeneca AB (SE) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001012187-A2 | BENZOIC ACID DERIVATIVES AND THEIR USE AS PPAR RECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2001-02-22 | — | — | WO | disclosed |