Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.53 |
| ▸ | MMP9 | P14780 | 8/20 | 0.53 |
| ▸ | MMP8 | P22894 | 2/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476074 | 1.00 | MMP2 (0.53) | MMP2MMP9MMP8MMP13MMP3 | |
| SCHEMBL7476592 | 0.77 | MMP2 (0.80) | MMP2MMP9MMP8MMP13MMP3 | |
| SCHEMBL8553779 | 0.77 | MMP2 (0.61) | MMP2MMP9MMP8MMP13MMP3 | |
| SCHEMBL2579539 | 0.77 | LMNA (0.72) | ALDH1A1LMNACYP3A4HIF1AMAPK1 | |
| SCHEMBL7473915 | 0.76 | MMP2 (0.61) | MMP2MMP9MMP8MMP13MMP3 | |
| SCHEMBL7484264 | 0.74 | MMP8 (0.59) | MMP2MMP9MMP8MMP13MMP3 | |
| SCHEMBL7474147 | 0.74 | MMP2 (0.64) | MMP2MMP9MMP8MMP13MMP3 | |
| SCHEMBL17550629 | 0.71 | LMNA (0.56) | ALDH1A1LMNACYP3A4HIF1AMAPK1 | |
| SCHEMBL8551651 | 0.71 | MMP2 (0.56) | MMP2MMP9MMP8MMP13MMP3 | |
| SCHEMBL613704 | 0.70 | LTA4H (0.77) | ALDH1A1LMNACYP3A4HIF1AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |