Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | GRM8 | O00222 | 1/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | RORA | P35398 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8006905 | 0.98 | ADRB2 (0.39) | ADRB2ADRB1ADRB3ALDH1A1CNR2 | |
| SCHEMBL996782 | 0.84 | HDAC4 (0.44) | ADRB2CNR2CNR1MAPT | |
| SCHEMBL5572682 | 0.84 | MAPT (0.49) | ALDH1A1MAPTCYP2C9HIF1AKDM4E | |
| SCHEMBL4984142 | 0.84 | MAPT (0.49) | ALDH1A1MAPTCYP2C9HIF1AKDM4E | |
| SCHEMBL7039133 | 0.81 | NPSR1 (0.50) | ADRB3ALDH1A1GRM8GRM4MAPT | |
| SCHEMBL8188747 | 0.75 | CSK (0.45) | ADRB2ADRB1ADRB3RAB9AEPHX2 | |
| SCHEMBL4872444 | 0.74 | MAPT (0.41) | ALDH1A1CNR2GRM8GRM7GRM4 | |
| SCHEMBL5573778 | 0.72 | ROCK2 (0.46) | ALDH1A1 | |
| SCHEMBL9620180 | 0.72 | SLC6A3 (0.47) | ADRB2ADRB1ADRB3ALDH1A1CNR2 | |
| SCHEMBL2357009 | 0.71 | LMNA (0.37) | ADRB2ADRB1ADRB3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211228-B1 | COMPOUNDS WITH AMINO, GUANIDINO AND AMIDINO HETEROCYCLIC COMPOUNDS | AXYS PHARMACEUTICALS, INC | 2001-04-03 | — | — | US | disclosed |
| US-6022969-A | Compositions and methods for treating mast-cell mediated conditions | AXYS PHARMACEUTICALS, INC. (US) | 2000-02-08 | — | — | US | disclosed |
| EP-0763016-B1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL MEDIATED CONDITIONS | AXYS PHARM INC (US) | 2000-01-26 | — | — | EP | disclosed |
| US-5656660-A | AMINE OR GUANIDINE GROUP-CONTAINING TRYPTASE INHIBITOR | ARRIS PHARMACEUTICAL CORPORATION (US) | 1997-08-12 | — | — | US | disclosed |
| EP-0782571-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1997-07-09 | — | — | EP | disclosed |
| EP-0763016-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL MEDIATED CONDITIONS | ARRIS PHARMACEUTICAL CORPORATION (US) | 1997-03-19 | — | — | EP | disclosed |
| WO-1996009297-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1996-03-28 | — | — | WO | disclosed |
| WO-1995032945-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL MEDIATED CONDITIONS | ARRIS PHARMACEUTICAL CORPORATION (US) | 1995-12-07 | — | — | WO | disclosed |