Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 4/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 5/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477800 | 0.81 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2NPC1RAB9AACHE | |
| SCHEMBL7480814 | 0.78 | KMT2A (0.46) | ALDH1A1SMN1; SMN2NPC1RAB9ANAMPT | |
| SCHEMBL7482069 | 0.77 | NPC1 (0.36) | ALDH1A1SMN1; SMN2NPC1RAB9AITGB3 | |
| SCHEMBL7480938 | 0.75 | NPC1 (0.43) | ALDH1A1SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL7474257 | 0.74 | MEN1 (0.44) | ALDH1A1SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL27528778 | 0.72 | GRIN2B (0.39) | NPC1RAB9AITGB3ITGAVITGA2B | |
| SCHEMBL7482791 | 0.71 | MAPK1 (0.41) | ALDH1A1SMN1; SMN2NPC1RAB9ANAMPT | |
| SCHEMBL7477791 | 0.68 | NPC1 (0.42) | ALDH1A1SMN1; SMN2NPC1RAB9AF2 | |
| SCHEMBL7489390 | 0.68 | LIPE (0.61) | NPC1RAB9ABCHELIPENAMPT | |
| SCHEMBL5566351 | 0.66 | ACHE (0.52) | ALDH1A1SMN1; SMN2NPC1RAB9AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950056-B1 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2002-09-18 | — | — | EP | claimed |
| EP-0950056-B1 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2002-09-18 | — | — | EP | disclosed |
| US-6004977-A | ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |