Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.37 |
| ▸ | BCL2 | P10415 | 2/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 6/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5898009 | 0.91 | PPARG (0.42) | PLA2G4APLAUPPARG | |
| SCHEMBL6595653 | 0.72 | MMP3 (0.41) | PPARG | |
| SCHEMBL4934703 | 0.71 | PLA2G4A (0.55) | NR1H2PPARANR1H3PLA2G4AMCL1 | |
| SCHEMBL28586559 | 0.71 | RORC (0.50) | PPARAPLA2G4AMCL1BCL2PLG | |
| SCHEMBL1664063 | 0.70 | PLG (0.51) | PLA2G4AMCL1BCL2RAPGEF4PLG | |
| SCHEMBL1749895 | 0.69 | PLA2G4A (0.59) | NR1H2PPARANR1H3PLA2G4AMCL1 | |
| SCHEMBL5387474 | 0.69 | TUBB4A (0.59) | PLA2G4ARAPGEF4PLGPLAUPPARG | |
| SCHEMBL6752488 | 0.68 | HTR2C (0.55) | PLA2G4ARAPGEF4PLGPLAU | |
| SCHEMBL1809906 | 0.68 | HCAR3 (0.53) | PLA2G4AMCL1BCL2PLGPLAU | |
| SCHEMBL846081 | 0.68 | PLA2G4A (0.61) | NR1H2PPARANR1H3PLA2G4AMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263755-A2 | CYCLIC BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | Bristol-Myers Squibb Pharma Company (US) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001070673-A2 | CYCLIC β-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-$g(a) | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |