Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 4/20 | 0.41 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | DCLRE1B | Q9H816 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | DCLRE1A | Q6PJP8 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477639 | 0.89 | TSHR (0.51) | F2DHODHTSHRKDM4EALDH1A1 | |
| SCHEMBL7475485 | 0.79 | MMP12 (0.42) | F2TSHRKDM4EALDH1A1NFKB1 | |
| SCHEMBL7482853 | 0.77 | HRH3 (0.50) | F2TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL7478027 | 0.73 | ALDH1A1 (0.48) | TSHRKDM4EALDH1A1LMNAHSD17B10 | |
| SCHEMBL20494483 | 0.72 | KDM4E (0.76) | TSHRKDM4EPDPK1ALDH1A1LMNA | |
| SCHEMBL7474003 | 0.71 | HRH3 (0.60) | F2TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL12597050 | 0.71 | PPARG (0.55) | TSHRLMNANPC1GPR17 | |
| SCHEMBL7474368 | 0.71 | KDM4E (0.52) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL19953414 | 0.70 | LOXL2 (0.57) | PCSK9 | |
| SCHEMBL4872353 | 0.70 | TSHR (0.72) | TSHRALDH1A1HPGDCYP2C19CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210343-A2 | BENZOIC ACID DERIVATIVES AND THEIR USE AS PPAR RECEPTOR AGONISTS | AstraZeneca AB (SE) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001012187-A2 | BENZOIC ACID DERIVATIVES AND THEIR USE AS PPAR RECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2001-02-22 | — | — | WO | disclosed |