Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL749300 | 0.89 | ALDH1A1 (0.40) | ALDH1A1MAPTHPGDSMN1; SMN2KDM4E | |
| SCHEMBL745512 | 0.88 | OPRM1 (0.34) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL746591 | 0.87 | PARP1 (0.33) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL747110 | 0.87 | OPRM1 (0.34) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL751012 | 0.86 | PARP1 (0.36) | MAPT | |
| SCHEMBL747155 | 0.86 | TP53 (0.38) | MAPTKDM4EMEN1KMT2ANPSR1 | |
| Hydrochloric Acid SCHEMBL747648 | 0.85 | PARP1 (0.36) | MAPT | |
| SCHEMBL747122 | 0.85 | TP53 (0.33) | MAPT | |
| Hydrochloric Acid SCHEMBL748268 | 0.85 | TP53 (0.38) | MAPTKDM4EMEN1KMT2ANPSR1 | |
| Hydrochloric Acid SCHEMBL748492 | 0.85 | TP53 (0.33) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | claimed |
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | disclosed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | disclosed |