Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP5 | Q13451 | 1/20 | 0.52 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.52 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | SIRT5 | Q9NXA8 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL9437142 | 0.93 | CRBN (0.59) | FKBP5CRBNOR51E2KDM4EGAA | |
| SCHEMBL6764194 | 0.92 | FKBP5 (0.57) | FKBP5CRBNOR51E2KDM4EGAA | |
| Succinic Acid SCHEMBL8104684 | 0.86 | CRBN (0.64) | FKBP5CRBNOR51E2KDM4EGAA | |
| 5-Aminovaleric Acid SCHEMBL28827887 | 0.86 | NFKB1 (0.50) | FKBP5CRBNOR51E2KDM4EGAA | |
| Hexanoate SCHEMBL11045296 | 0.86 | AKR1B1 (0.50) | FKBP5CRBNOR51E2TSHRTDP1 | |
| Aminocaproic Acid SCHEMBL11214069 | 0.84 | LMNA (0.52) | FKBP5CRBNOR51E2KDM4EGAA | |
| SCHEMBL261431 | 0.84 | LMNA (0.52) | FKBP5CRBNOR51E2KDM4EGAA | |
| Myristic Acid SCHEMBL782903 | 0.84 | GPR84 (0.52) | FKBP5CRBNOR51E2POLBLMNA | |
| 12-Aminododecanoic Acid SCHEMBL6670903 | 0.84 | LMNA (0.52) | FKBP5CRBNOR51E2KDM4EGAA | |
| Adipic Acid SCHEMBL262118 | 0.84 | LMNA (0.52) | FKBP5CRBNOR51E2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0637509-B1 | A tube for fuel transportation | NITTA MOORE CO LTD (JP) | 2002-10-23 | — | — | EP | disclosed |
| US-6355321-B1 | FOR USE AS A FUEL TUBE IN TRANSPORTATION VEHICLES SUCH AS AUTOMOBILES; BARRIERING PROPERTIES (BARRIER ACTION) AGAINST NOT ONLY A GASOLINE-BASED FUEL, BUT ALSO A MIXED FUEL INCLUDING ALCOHOLS, AND IS KINK-PROOF | NITTA MOORE COMPANY (JP) | 2002-03-12 | — | — | US | disclosed |
| US-6089278-A | Tube for fuel transportation | NITTA MOORE COMPANY (JP) | 2000-07-18 | — | — | US | disclosed |
| EP-0637509-A1 | A tube for fuel transportation | NITTA MOORE COMPANY (JP) | 1995-02-08 | — | — | EP | disclosed |