Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.59 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.59 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | SIRT5 | Q9NXA8 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6764194 | 0.98 | FKBP5 (0.57) | CRBNFKBP5OR51E2KDM4EGAA | |
| Adipic Acid SCHEMBL7485159 | 0.93 | FKBP5 (0.52) | CRBNFKBP5OR51E2KDM4EGAA | |
| Succinic Acid SCHEMBL8104684 | 0.92 | CRBN (0.64) | CRBNFKBP5OR51E2KDM4EGAA | |
| Hexanoate SCHEMBL11045296 | 0.92 | AKR1B1 (0.50) | CRBNFKBP5OR51E2TSHRSLC22A6 | |
| 5-Aminovaleric Acid SCHEMBL28827887 | 0.92 | NFKB1 (0.50) | CRBNFKBP5OR51E2KDM4EGAA | |
| SCHEMBL261431 | 0.91 | LMNA (0.52) | CRBNFKBP5OR51E2KDM4EGAA | |
| Adipic Acid SCHEMBL262118 | 0.91 | LMNA (0.52) | CRBNFKBP5OR51E2KDM4EGAA | |
| Aminocaproic Acid SCHEMBL11214069 | 0.91 | LMNA (0.52) | CRBNFKBP5OR51E2KDM4EGAA | |
| 12-Aminododecanoic Acid SCHEMBL6670903 | 0.91 | LMNA (0.52) | CRBNFKBP5OR51E2KDM4EGAA | |
| Myristic Acid SCHEMBL782903 | 0.91 | GPR84 (0.52) | CRBNFKBP5OR51E2POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114920923-A | Process method for continuously polymerizing ammonium carboxylate and caprolactam | 天津长芦海晶集团有限公司 | 2022-08-19 | — | — | CN | disclosed |
| CN-103555643-A | Microorganisms for the production of adipic acid and other compounds | GENOMATICA INC | 2014-02-05 | — | — | CN | disclosed |
| CN-102066551-B | Microorganisms for the production of adipic acid and other compounds | GENOMATICA INC | 2013-10-09 | — | — | CN | disclosed |
| CN-102066551-A | Microorganisms for the production of adipic acid and other compounds | GENOMATICA INC | 2011-05-18 | — | — | CN | disclosed |
| US-5298558-A | Electrostatic dissipative blends of PVC, polyetheramides and an impact modifier | THE GEON COMPANY (US) | 1994-03-29 | — | — | US | disclosed |