Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY2 | P41231 | 14/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7495877 | 0.91 | P2RY2 (0.46) | P2RY2LMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL7490690 | 0.88 | P2RY2 (0.40) | P2RY2BRD4LMNAKDM4EMEN1 | |
| SCHEMBL7841237 | 0.82 | LMNA (0.42) | BRD4LMNAALDH1A1 | |
| SCHEMBL7491391 | 0.80 | P2RY2 (0.39) | P2RY2LMNAKDM4EMEN1ALDH1A1 | |
| SCHEMBL7507931 | 0.79 | P2RY2 (0.47) | P2RY2MAPTRXFP1 | |
| SCHEMBL7504709 | 0.78 | P2RY2 (0.39) | P2RY2 | |
| SCHEMBL7488455 | 0.78 | ATAD2 (0.40) | P2RY2LMNAKDM4EMEN1ALDH1A1 | |
| SCHEMBL7840949 | 0.77 | P2RY2 (0.39) | P2RY2LMNAKDM4EMEN1ALDH1A1 | |
| SCHEMBL7492166 | 0.75 | LMNA (0.43) | BRD4LMNAALDH1A1 | |
| SCHEMBL7490270 | 0.75 | P2RY2 (0.35) | P2RY2BRD4KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996617-B1 | 2,4-Dithi(oxo)-pyridin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRAZENECA AB (SE) | 2002-01-09 | — | — | EP | disclosed |
| US-6107297-A | 2,4-Dithi(oxo)-pyrimidin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-08-22 | — | — | US | disclosed |