Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841237 | 0.92 | LMNA (0.42) | LMNAALDH1A1BRD4 | |
| SCHEMBL7490690 | 0.86 | P2RY2 (0.40) | LMNAALDH1A1BRD4 | |
| SCHEMBL7491592 | 0.85 | ALDH1A1 (0.45) | LMNAALDH1A1BRD4 | |
| SCHEMBL7840949 | 0.77 | P2RY2 (0.39) | LMNAALDH1A1 | |
| SCHEMBL7507165 | 0.76 | LMNA (0.34) | LMNABRD4 | |
| SCHEMBL7488455 | 0.75 | ATAD2 (0.40) | LMNAALDH1A1 | |
| SCHEMBL7507735 | 0.75 | LMNA (0.38) | LMNAALDH1A1BRD4 | |
| SCHEMBL7831877 | 0.72 | KMT2A (0.39) | LMNAALDH1A1 | |
| SCHEMBL7841890 | 0.70 | LMNA (0.36) | LMNAALDH1A1 | |
| SCHEMBL7840803 | 0.70 | ATAD2 (0.38) | LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996617-B1 | 2,4-Dithi(oxo)-pyridin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRAZENECA AB (SE) | 2002-01-09 | — | — | EP | disclosed |
| US-6107297-A | 2,4-Dithi(oxo)-pyrimidin-5-yl compounds bearing a tricyclic substituent useful as P2 purinoceptor antagonists | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-08-22 | — | — | US | disclosed |