SCHEMBL7488496

SCHEMBL7488496

O=C1C=C(c2ccc(CS)cc2)CC1

nearest known ligand 0.42

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 5/20 0.38
ALDH1A1 P00352 3/20 0.33
MEN1 O00255 1/20 0.33
MAPK1 P28482 1/20 0.33
KMT2A Q03164 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
FOLH1 Q04609 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL728223 0.72 NPC1 (0.39) ALDH1A1MEN1MAPK1KMT2ASMN1; SMN2
SCHEMBL5228519 0.72 HTR2C (0.39) ALDH1A1MEN1MAPK1KMT2ASMN1; SMN2
SCHEMBL7973057 0.72 HSD11B1 (0.36) ALDH1A1NPC1RAB9A
SCHEMBL731336 0.72 NPC1 (0.50) ALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL17756329 0.69 IDO1 (0.58) IDO1FOLH1
SCHEMBL441726 0.69 IDO1 (0.58) IDO1FOLH1
SCHEMBL17756332 0.69 IDO1 (0.58) IDO1FOLH1
SCHEMBL24923799 0.68 ALDH1A1 (0.44) ALDH1A1MEN1MAPK1KMT2ASMN1; SMN2
SCHEMBL10697684 0.68 KIF11 (0.41) ALDH1A1MEN1MAPK1KMT2ASMN1; SMN2
SCHEMBL8649025 0.68 PTGS2 (0.42) ALDH1A1MEN1MAPK1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0904269-B1 3,4-DIARYL-2-HYDROXY-2,5-DIHYDROFURANS AS PRODRUGS TO COX-2 INHIBITORS MERCK FROSST CANADA INC (CA) 2002-01-23 EP disclosed
US-6057319-A CYCLOOXYGENASE-2 INHIBITORS; NON-STEROIDAL ANTIINFLAMMATORY AGENTS MERCK FROSST CANADA & CO. (CA) 2000-05-02 US disclosed
EP-0904269-A1 3,4-DIARYL-2-HYDROXY-2,5-DIHYDROFURANS AS PRODRUGS TO COX-2 INHIBITORS MERCK FROSST CANADA INC. (CA) 1999-03-31 EP disclosed
EP-0863134-A1 2-(3,5-difluorophenyl)-3-(4-(methyl-sulfonyl)phenyl)-2-cyclopenten-1-one useful as an inhibitor of cyclooxygenase-2 MERCK FROSST CANADA INC. (CA) 1998-09-09 EP disclosed
US-5698584-A NON-STEROIDAL ANTIINFLAMMATORY AGENTS MERCK FROSST CANADA, INC. (CA) 1997-12-16 US disclosed
WO-1997016435-A1 3,4-DIARYL-2-HYDROXY-2,5-DIHYDROFURANS AS PRODRUGS TO COX-2 INHIBITORS MERCK FROSST CANADA INC. (CA) 1997-05-09 WO disclosed