Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORD | Q00796 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 3/20 | 0.47 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.44 |
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13033969 | 0.90 | ACHE (0.56) | SORDACHESLC6A7 | |
| SCHEMBL7490520 | 0.83 | ACHE (0.47) | ACHEHRH3HTR1AHTR2ADRD3 | |
| SCHEMBL7495396 | 0.83 | HTR1A (0.46) | ACHEHRH3HTR1AHTR2ADRD3 | |
| SCHEMBL7486793 | 0.82 | HTR1A (0.53) | SORDHTR1AKCNH2 | |
| SCHEMBL7488440 | 0.81 | HTR1A (0.58) | HRH3HTR1AHTR2ADRD3DRD2 | |
| SCHEMBL15344948 | 0.79 | SORD (0.52) | SORDACHESLC6A7 | |
| SCHEMBL13532646 | 0.79 | HTR1A (0.66) | SORDACHESLC6A7HTR1ADRD3 | |
| SCHEMBL13532629 | 0.77 | SIGMAR1 (0.68) | HTR1ADRD3DRD2 | |
| SCHEMBL9488628 | 0.77 | SORD (0.56) | SORDACHESLC6A7HRH3 | |
| SCHEMBL8558871 | 0.76 | HTR1A (0.76) | HTR1AHTR2ADRD3DRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023287-B1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PF MEDICAMENT (FR) | 2002-06-12 | — | — | EP | disclosed |
| US-6303603-B1 | FOR THEARPY OF ANXIETY, DEPRESSION, SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2001-10-16 | — | — | US | disclosed |
| EP-1023287-A1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PIERRE FABRE MEDICAMENT (FR) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999020622-A1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PIERRE FABRE MEDICAMENT (FR) | 1999-04-29 | — | — | WO | disclosed |