Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | DBH | P09172 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA7 | P43166 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.43 |
| ▸ | BLM | P54132 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7496442 | 0.83 | LMNA (0.40) | MAPTCA12CA1CA2CA7 | |
| SCHEMBL7496809 | 0.81 | CA12 (0.45) | KDM4EGAARECQLMAPTPOLB | |
| SCHEMBL7493860 | 0.80 | SMN1; SMN2 (0.46) | KDM4EGAAMAPTSLC6A2SMN1; SMN2 | |
| SCHEMBL7434063 | 0.80 | CES2 (0.43) | MAPTL3MBTL1TDP1TSHRSMN1; SMN2 | |
| SCHEMBL7430292 | 0.79 | CYP1A2 (0.49) | KDM4EGAACA12CA14NFKB1 | |
| SCHEMBL7500101 | 0.79 | NPC1 (0.41) | GAAPOLBCA1CA2TSHR | |
| SCHEMBL7436814 | 0.78 | SMN1; SMN2 (0.47) | KDM4EGAAMAPTL3MBTL1PTGS2 | |
| SCHEMBL7435408 | 0.77 | ALDH1A1 (0.51) | MAPTPOLBCA1CA2CYP1A2 | |
| SCHEMBL7497110 | 0.77 | ALDH1A1 (0.46) | GAAMAPTPOLBTDP1LMNA | |
| SCHEMBL7488146 | 0.75 | SLC7A5 (0.44) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4453003-A | ENZYME INHIBITORS, ANTIINFLAMMATORY AGENTS | UMEZAWA HAMAO (JP) | 1984-06-05 | — | — | US | disclosed |
| US-4391986-A | Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediates therefor and process for producing them | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1983-07-05 | — | — | US | disclosed |
| US-4281180-A | Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediated therefor and process for producing them | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1981-07-28 | — | — | US | disclosed |