Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | FPR2 | P25090 | 4/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7496442 | 0.86 | LMNA (0.40) | LMNAALDH1A1CA12CA14CES2 | |
| SCHEMBL7434063 | 0.85 | CES2 (0.43) | LMNAALDH1A1SMN1; SMN2CES2CES1 | |
| SCHEMBL7500101 | 0.84 | NPC1 (0.41) | ALDH1A1GAACES2CES1KMT2A | |
| SCHEMBL7436814 | 0.83 | SMN1; SMN2 (0.47) | LMNAALDH1A1SMN1; SMN2GAAACACB | |
| SCHEMBL7435408 | 0.82 | ALDH1A1 (0.51) | CYP1A2ALDH1A1ACACBCES2CES1 | |
| SCHEMBL7497110 | 0.82 | ALDH1A1 (0.46) | LMNAALDH1A1GAAACACBKMT2A | |
| SCHEMBL7437066 | 0.80 | KMT2A (0.51) | LMNAALDH1A1SMN1; SMN2ACACBKMT2A | |
| SCHEMBL7493041 | 0.80 | L3MBTL1 (0.47) | LMNAALDH1A1GAAACACBKMT2A | |
| SCHEMBL7490643 | 0.79 | KDM4E (0.50) | CYP1A2LMNACA12CA14SMN1; SMN2 | |
| SCHEMBL7485958 | 0.79 | NPSR1 (0.54) | CYP1A2LMNASMN1; SMN2GAAACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4453003-A | ENZYME INHIBITORS, ANTIINFLAMMATORY AGENTS | UMEZAWA HAMAO (JP) | 1984-06-05 | — | — | US | disclosed |
| US-4391986-A | Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediates therefor and process for producing them | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1983-07-05 | — | — | US | disclosed |
| US-4281180-A | Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediated therefor and process for producing them | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1981-07-28 | — | — | US | disclosed |