Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL750950 | 0.91 | SRC (0.36) | SRCCDK8CLK4WDR5SIGMAR1 | |
| Hydrochloric Acid SCHEMBL751875 | 0.90 | SRC (0.36) | SRCCDK8CLK4WDR5SIGMAR1 | |
| SCHEMBL748611 | 0.85 | TP53 (0.38) | SIGMAR1TP53CYP1A2CYP2D6TSHR | |
| SCHEMBL747960 | 0.83 | CDK8 (0.32) | CDK8CLK4SIGMAR1TP53CYP1A2 | |
| Hydrochloric Acid SCHEMBL748195 | 0.83 | CDK8 (0.32) | CDK8CLK4SIGMAR1TP53CYP1A2 | |
| SCHEMBL751895 | 0.81 | DHODH (0.33) | CDK8CLK4WDR5SIGMAR1TP53 | |
| SCHEMBL746739 | 0.80 | SRC (0.37) | SRCTP53KDM4EMAPTHDAC1 | |
| Hydrochloric Acid SCHEMBL750002 | 0.80 | DHODH (0.33) | CDK8CLK4SIGMAR1TP53CYP1A2 | |
| SCHEMBL748640 | 0.79 | TACR3 (0.32) | CDK8CLK4SIGMAR1TP53CYP1A2 | |
| SCHEMBL750133 | 0.79 | SRC (0.36) | SRCSIGMAR1TP53CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | claimed |