SCHEMBL7494302

SCHEMBL7494302

CN1CCN(c2cc(CC=O)cc(Cc3ccccc3)c2)CC1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.45
AGXT P21549 1/20 0.45
HTR6 P50406 5/20 0.44
HRH4 Q9H3N8 3/20 0.44
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
KIF11 P52732 1/20 0.43
HRH1 P35367 2/20 0.43
HTR2A P28223 2/20 0.41
HTR1A P08908 1/20 0.41
ADRA2A P08913 1/20 0.41
ADRA2B P18089 1/20 0.41
ADRA2C P18825 1/20 0.41
DRD1 P21728 1/20 0.41
HRH2 P25021 1/20 0.41
HTR1B P28222 1/20 0.41
HTR2C P28335 1/20 0.41
HTR1E P28566 1/20 0.41
SLC6A4 P31645 1/20 0.41
HTR2B P41595 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7077564 0.80 AGXT (0.47) AGXTHTR6HRH4NPC1RAB9A
SCHEMBL7077276 0.78 LMNA (0.49) ALDH1A1AGXTHTR6HRH4NPC1
SCHEMBL7582559 0.77 NCF1 (0.57) ALDH1A1HTR6HRH4NPC1RAB9A
SCHEMBL6473253 0.75 ALDH1A1 (0.65) ALDH1A1NPC1RAB9AADRA2CSIRT6
SCHEMBL27997453 0.74 AGXT (0.47) AGXTHTR6HRH4NPC1RAB9A
SCHEMBL6946070 0.74 PLOD2 (0.46) HTR6HRH4NPC1RAB9AHRH1
SCHEMBL3689290 0.71 ALDH1A1 (0.55) ALDH1A1HRH4NPC1RAB9AKIF11
SCHEMBL4577362 0.71 AGXT (0.57) ALDH1A1AGXTHTR6HTR2AHTR1A
SCHEMBL7011745 0.71 TSHR (0.46)
SCHEMBL27470112 0.70 NCF1 (0.47) AGXTHRH4HRH1HTR3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1196384-A4 1-(AROMATIC- OR HETEROAROMATIC-SUBSTITUTED)-3-(HETEROAROMATIC SUBSTITUTED)-1,3-PROPANEDIONES AND USES THEREOF MERCK & CO INC (US) 2002-10-23 EP disclosed
EP-1196384-A1 1-(AROMATIC- OR HETEROAROMATIC-SUBSTITUTED)-3-(HETEROAROMATIC SUBSTITUTED)-1,3-PROPANEDIONES AND USES THEREOF Merck & Co., Inc. (US) 2002-04-17 EP disclosed
WO-2001000578-A1 1-(AROMATIC- OR HETEROAROMATIC-SUBSTITUTED)-3-(HETEROAROMATIC SUBSTITUTED)-1,3-PROPANEDIONES AND USES THEREOF MERCK & CO., INC. (US) 2001-01-04 WO disclosed