Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6491260 | 0.80 | MAOA (0.55) | CYP1A2CYP3A4ADRA2AMAOASLC6A2 | |
| SCHEMBL3979494 | 0.79 | CYP1A2 (0.48) | CYP1A2CYP3A4ADRA2AMAOASLC6A2 | |
| SCHEMBL8100059 | 0.74 | SIGMAR1 (0.67) | SIGMAR1MAPTHPGDL3MBTL1 | |
| SCHEMBL4981271 | 0.74 | PIK3CD (0.39) | CYP1A2ADRA2AMAOASLC6A2HTR2C | |
| SCHEMBL1931259 | 0.73 | ABL1 (0.50) | CYP1A2CYP3A4ADRA2AMAOASLC6A2 | |
| SCHEMBL27585673 | 0.73 | RAB9A (0.60) | CYP1A2CYP3A4ADRA2AMAOASLC6A2 | |
| Fluorene SCHEMBL27895221 | 0.72 | KCNH2 (0.53) | CYP3A4SIGMAR1HTR2AADRA2ASLC6A2 | |
| Fluorene SCHEMBL27895220 | 0.72 | KCNH2 (0.53) | CYP3A4SIGMAR1HTR2AADRA2ASLC6A2 | |
| SCHEMBL3465634 | 0.72 | L3MBTL1 (0.69) | SIGMAR1MAPTHPGDL3MBTL1 | |
| Fluorene SCHEMBL22720649 | 0.72 | ALDH1A1 (0.51) | HTR2AHRH1MAOANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1248777-A2 | TRICYCLIC COMPOUNDS WITH ANTIVIRAL ACTIVITY | WARNER-LAMBERT COMPANY (US) | 2002-10-16 | — | — | EP | claimed |
| WO-2001051479-A2 | TRICYCLIC COMPOUNDS WITH ANTIVIRAL ACTIVITY | WARNER-LAMBERT COMPANY (US) | 2001-07-19 | — | — | WO | claimed |