Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318831 | 0.85 | KDM4E (0.43) | KDM4EL3MBTL1SMN1; SMN2EGFRTDP1 | |
| SCHEMBL6616007 | 0.84 | KDM4E (0.42) | KDM4EL3MBTL1SMN1; SMN2EGFRTDP1 | |
| Potassium Ion SCHEMBL7501745 | 0.83 | ALDH1A1 (0.38) | SMN1; SMN2MAPT | |
| SCHEMBL13576829 | 0.83 | KDM4E (0.53) | KDM4EL3MBTL1SMN1; SMN2EGFRTDP1 | |
| SCHEMBL6616106 | 0.79 | NR4A1 (0.44) | KDM4EL3MBTL1RAD51TDP1ACLY | |
| SCHEMBL12508637 | 0.78 | KDM4E (0.49) | KDM4EL3MBTL1SMN1; SMN2EGFRTDP1 | |
| SCHEMBL68310 | 0.76 | KDM4E (0.56) | KDM4EL3MBTL1SMN1; SMN2EGFRTDP1 | |
| SCHEMBL8934094 | 0.75 | CASP1 (0.48) | KDM4EL3MBTL1SMN1; SMN2EGFRTDP1 | |
| Potassium Ion SCHEMBL6991489 | 0.75 | RAD52 (0.42) | KDM4ERAD51THRBNR4A1SLC2A1 | |
| SCHEMBL7020846 | 0.75 | THRB (0.42) | THRBNR4A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906313-B1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2004-03-03 | — | — | EP | disclosed |
| EP-1082325-A4 | NAPHTHOSULFAMYLMETHYL PENEM ANTIBACTERIALS | MERCK & CO INC (US) | 2002-02-06 | — | — | EP | disclosed |
| EP-1032384-A4 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-1027353-A4 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-1023271-A4 | PROCESS FOR THE SYNTHESIS OF CARBAPENEM INTERMEDIATES, AND COMPOUNDS PRODUCED | MERCK & CO INC (US) | 2001-09-12 | — | — | EP | disclosed |
| US-6271222-B1 | ANTIBIOTIC | MERCK & CO., INC. | 2001-08-07 | — | — | US | disclosed |
| US-6235898-B1 | CARBAPENEMS ARE SUBSTITUTED AT THE 2-POSITION WITH 1,8-NAPHTHOSULTAM-N-METHYL GROUPS | MERCK & CO., INC. | 2001-05-22 | — | — | US | disclosed |
| US-6207823-B1 | ANTIBIOTIC; ANTIBIOTIC RESISTANT INFECTIONS | MERCK & CO., INC. | 2001-03-27 | — | — | US | disclosed |
| EP-1082325-A1 | NAPHTHOSULFAMYLMETHYL PENEM ANTIBACTERIALS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| EP-1032384-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2000-09-06 | — | — | EP | disclosed |
| EP-1023271-A1 | PROCESS FOR THE SYNTHESIS OF CARBAPENEM INTERMEDIATES, AND COMPOUNDS PRODUCED | Merck & Co., Inc. (US) | 2000-08-02 | — | — | EP | disclosed |
| US-6048978-A | Process for the synthesis of carbapenem intermediates, and compounds produced | MERCK & CO., INC. (US) | 2000-04-11 | — | — | US | disclosed |
| WO-1999061448-A1 | NAPHTHOSULFAMYLMETHYL PENEM ANTIBACTERIALS | MERCK & CO., INC. (US) | 1999-12-02 | — | — | WO | disclosed |
| US-5994343-A | ANTIBIOTICS | MERCK & CO., INC. (US) | 1999-11-30 | — | — | US | disclosed |
| WO-1999020270-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 1999-04-29 | — | — | WO | disclosed |
| WO-1999018078-A1 | PROCESS FOR THE SYNTHESIS OF CARBAPENEM INTERMEDIATES, AND COMPOUNDS PRODUCED | MERCK & CO., INC. (US) | 1999-04-15 | — | — | WO | disclosed |
| WO-1999018107-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 1999-04-15 | — | — | WO | disclosed |
| EP-0906313-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 1999-04-07 | — | — | EP | disclosed |
| US-5756725-A | CARBAPENEM NUCLEUS IS SUBSTITUTED AT THE 2-POSITION WITH A NAPHTHOSULTAM LINKED THROUGH A CH2 GROUP | MERCK & CO., INC. (US) | 1998-05-26 | — | — | US | disclosed |
| WO-1997040048-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 1997-10-30 | — | — | WO | disclosed |