Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7168931 | 0.82 | SMN1; SMN2 (0.51) | PDE10ACYSLTR1NPC1RAB9AKDM4E | |
| SCHEMBL9081199 | 0.78 | CYSLTR1 (0.61) | PDE10ACYSLTR1 | |
| SCHEMBL6597830 | 0.77 | SORD (0.47) | PDE10ACYSLTR1KDM4EPOLBMAPT | |
| SCHEMBL10669295 | 0.74 | CYSLTR1 (0.57) | PDE10ACYSLTR1NPC1RAB9AMAPK1 | |
| SCHEMBL8144813 | 0.73 | CYSLTR1 (0.66) | PDE10ACYSLTR1SMN1; SMN2ALOX5 | |
| SCHEMBL30824487 | 0.73 | TSHR (0.41) | PDE10ACYSLTR1KDM4ESTAT3HTT | |
| SCHEMBL27595473 | 0.70 | SMN1; SMN2 (0.51) | PDE10ACYSLTR1NPC1RAB9AKDM4E | |
| SCHEMBL8112158 | 0.70 | PDE10A (0.47) | PDE10ACYSLTR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10430121 | 0.70 | MAPT (0.42) | PDE10ACYSLTR1MEN1KMT2ANPC1 | |
| SCHEMBL28840069 | 0.69 | ALDH1A1 (0.38) | PDE10ACYSLTR1KMT2ARAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905133-B1 | Tetrazole derivatives as LTD4 and H1 antagonists | KOWA CO (JP) | 2002-04-24 | — | — | EP | disclosed |
| US-6121286-A | ANTILEUKOTRIENE ACTIVITY AND ANTIHISTAMINIC ACTIVITY, FOR TREATING ASTHMA; COMPOUNDS SUCH AS 6-METHOXY-3-(2-(3-(2-QUINOLYLMETHOXY)BENZYL)TETRAZOLYL)QUINOLIN-2-ONE | KOWA CO., LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| US-6117886-A | EXCELLENT ANTILEUKOTRIENE ACTIVITY AND ANTIHISTAMINIC ACTIVITY, AND IS USEFUL FOR THE PREVENTION AND TREATMENT OF, FOR EXAMPLE, ASTHMA. | KOWA CO., LTD. (JP) | 2000-09-12 | — | — | US | disclosed |
| EP-0905133-A1 | Tetrazole derivatives as LTD4 and H1 antagonists | KOWA CO. LTD. (JP) | 1999-03-31 | — | — | EP | disclosed |