Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7501938 | 0.82 | PDE10A (0.40) | SMN1; SMN2MAPTLMNACYSLTR1HTT | |
| SCHEMBL10669295 | 0.77 | CYSLTR1 (0.57) | SMN1; SMN2CYSLTR1NPC1RAB9APDE10A | |
| SCHEMBL6582909 | 0.76 | CYSLTR1 (0.61) | SMN1; SMN2MAPTHPGDHSD17B10CYSLTR1 | |
| SCHEMBL30824487 | 0.75 | TSHR (0.41) | SMN1; SMN2CYSLTR1HTTKDM4EPDE10A | |
| SCHEMBL6597830 | 0.72 | SORD (0.47) | MAPTHPGDGAAALDH1A1CYSLTR1 | |
| SCHEMBL8112158 | 0.72 | PDE10A (0.47) | SMN1; SMN2LMNACYSLTR1NPC1RAB9A | |
| SCHEMBL27595473 | 0.72 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTGAALMNACYSLTR1 | |
| SCHEMBL10430121 | 0.72 | MAPT (0.42) | MAPTGAAALDH1A1CYSLTR1KDM4E | |
| SCHEMBL28840069 | 0.71 | ALDH1A1 (0.38) | SMN1; SMN2GAAALDH1A1CYSLTR1KDM4E | |
| SCHEMBL9688234 | 0.71 | CYSLTR2 (0.41) | SMN1; SMN2MAPTGAALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345927-A1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002062789-A1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-08-15 | — | — | WO | disclosed |