Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 15/20 | 0.58 |
| ▸ | MMP13 | P45452 | 15/20 | 0.58 |
| ▸ | MMP1 | P03956 | 14/20 | 0.58 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 7/20 | 0.41 |
| ▸ | MMP3 | P08254 | 6/20 | 0.41 |
| ▸ | MMP8 | P22894 | 5/20 | 0.41 |
| ▸ | MMP14 | P50281 | 3/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 2/20 | 0.39 |
| ▸ | MMP16 | P51512 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7502278 | 0.84 | MMP13 (0.55) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL7595438 | 0.80 | MMP13 (0.57) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL7513672 | 0.77 | MMP13 (0.59) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL7513743 | 0.77 | MMP13 (0.61) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL7899733 | 0.75 | MMP13 (0.43) | MMP9MMP13MMP1MEP1BMMP2 | |
| SCHEMBL7516820 | 0.74 | MMP13 (0.54) | MMP9MMP13MMP1MMP2MMP3 | |
| SCHEMBL7516170 | 0.74 | GAA (0.49) | MMP9MMP13MMP1ADAM17ALDH1A1 | |
| SCHEMBL6932245 | 0.74 | MMP9 (0.74) | MMP9MMP13MMP1MMP2MMP8 | |
| SCHEMBL7502927 | 0.74 | MMP13 (0.53) | MMP9MMP13MMP1MEP1BMMP2 | |
| SCHEMBL6930669 | 0.73 | MMP13 (1.00) | MMP9MMP13MMP1MMP2ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165501-A1 | ALKENYL- AND ALKYNYL-CONTAINING METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2002-01-02 | — | — | EP | disclosed |
| US-6197770-B1 | ENZYME INHIBITORS; ANTIARTHRITIC AGENTS; BONE DISORDERS | THE PROCTER & GAMBLE CO. | 2001-03-06 | — | — | US | disclosed |
| WO-2000051975-A1 | ALKENYL- AND ALKYNYL-CONTAINING METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2000-09-08 | — | — | WO | disclosed |