Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | TYMS | P04818 | 5/20 | 0.48 |
| ▸ | DHFR | P00374 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RHEB | Q15382 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515639 | 0.85 | TYMS (0.51) | TYMSDHFRXDH | |
| SCHEMBL7515343 | 0.84 | TYMS (0.42) | RXFP1TYMSDHFREGFRLMNA | |
| SCHEMBL7515297 | 0.81 | ITGB2 (0.50) | TYMSDHFRALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7524669 | 0.81 | TYMS (0.51) | TYMSDHFRALDH1A1HAO1XDH | |
| SCHEMBL7518650 | 0.81 | TYMS (0.43) | TYMSDHFR | |
| SCHEMBL7518203 | 0.79 | TYMS (0.37) | TYMSHPGDLMNALTA4HXDH | |
| SCHEMBL7514845 | 0.78 | TYMS (0.42) | TYMSDHFRXDH | |
| SCHEMBL7519197 | 0.73 | MAPK11 (0.41) | TYMSKDM4EL3MBTL1 | |
| SCHEMBL7708406 | 0.72 | LTA4H (0.50) | RXFP1KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL23339220 | 0.71 | NOS1 (0.40) | TYMSKDM4EALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | disclosed |