Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.45 |
| ▸ | MTTP | P55157 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.43 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.42 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370837 | 0.92 | MTTP (0.48) | CYP19A1MTTPLRRK2AVPR2PTGER1 | |
| SCHEMBL8816546 | 0.92 | CYP19A1 (0.45) | CYP19A1LRRK2PTGER1MEN1KMT2A | |
| SCHEMBL7749370 | 0.91 | CYP19A1 (0.49) | CYP19A1LRRK2AVPR2AVPR1APTGER1 | |
| SCHEMBL7370671 | 0.88 | GCGR (0.41) | MTTPAVPR2AVPR1AMEN1KMT2A | |
| SCHEMBL7371809 | 0.87 | PTGER1 (0.46) | CYP19A1PTGER1KCNA3L3MBTL1TP53 | |
| SCHEMBL7376652 | 0.85 | PTGER1 (0.46) | CYP19A1MTTPPTGER1KCNA3L3MBTL1 | |
| SCHEMBL7377166 | 0.85 | AVPR2 (0.48) | AVPR2AVPR1AMEN1KMT2AL3MBTL1 | |
| SCHEMBL7374161 | 0.84 | AVPR2 (0.40) | MTTPAVPR2AVPR1AMEN1KMT2A | |
| SCHEMBL7375995 | 0.84 | CYP19A1 (0.51) | CYP19A1LRRK2MEN1KMT2AL3MBTL1 | |
| SCHEMBL7375499 | 0.84 | MTTP (0.47) | CYP19A1MTTPAVPR2PTGER1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211242-B1 | CARDIOVASCULAR DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0757670-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-01-13 | — | — | EP | disclosed |
| WO-1995029152-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-02 | — | — | WO | disclosed |