Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | BLK | P51451 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 2/20 | 0.38 |
| ▸ | CCNH | P51946 | 2/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990894 | 0.93 | EGFR (0.42) | EGFRLCKLYNBLKCDK7 | |
| SCHEMBL7987981 | 0.92 | EGFR (0.38) | EGFRLCKLYNBLKKCNH2 | |
| SCHEMBL7990969 | 0.92 | EGFR (0.38) | EGFRLCKLYNBLKCDK7 | |
| SCHEMBL7976911 | 0.92 | TNF (0.36) | EGFRLCKLYNBLKCDK7 | |
| SCHEMBL7994041 | 0.89 | KDR (0.41) | EGFRLCKLYNBLKCDK7 | |
| SCHEMBL7513288 | 0.86 | CDK7 (0.47) | CDK7CCNHMNAT1CCNT1CCNE1 | |
| SCHEMBL7990448 | 0.84 | CYP11B1 (0.40) | CDK7CCNHMNAT1CCNT1CCNE1 | |
| SCHEMBL7976272 | 0.83 | CCNT1 (0.41) | EGFRCDK7CCNHMNAT1CCNT1 | |
| SCHEMBL7986667 | 0.83 | CDK7 (0.44) | EGFRLCKLYNBLKCDK7 | |
| SCHEMBL7987305 | 0.80 | CCNT1 (0.42) | CDK7CCNHMNAT1CCNT1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |