Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29828186 | 0.95 | TSHR (0.41) | TSHRLMNAKMT2ANMT1CES2 | |
| Lithium Ion SCHEMBL7518786 | 0.95 | TSHR (0.41) | TSHRLMNAKMT2ANMT1CES2 | |
| SCHEMBL1465305 | 0.95 | TSHR (0.41) | TSHRLMNAKMT2ANMT1CES2 | |
| SCHEMBL1583998 | 0.77 | TSHR (0.38) | TSHRLMNAKMT2ANMT1ALDH1A1 | |
| SCHEMBL11859111 | 0.76 | G6PD (0.42) | G6PDALDH1A1TDP1 | |
| SCHEMBL345543 | 0.73 | TSHR (0.43) | TSHRLMNAKMT2ACES2CES1 | |
| Potassium Ion SCHEMBL11334527 | 0.73 | TP53 (0.42) | TSHRKMT2ANMT1ALDH1A1POLB | |
| Potassium Ion SCHEMBL3152587 | 0.71 | TSHR (0.41) | TSHRG6PDALDH1A1CYP2A6CYP1A2 | |
| SCHEMBL7518790 | 0.71 | TSHR (0.41) | TSHRLMNAKMT2ACES2CES1 | |
| SCHEMBL1465308 | 0.71 | TSHR (0.41) | TSHRLMNAKMT2ACES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1231197-A1 | Process for producing allyl halide compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2002-08-14 | — | — | EP | disclosed |
| US-20020107422-A1 | Process for producing allyl halide compound | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2002-08-08 | — | — | US | disclosed |
| EP-0599199-B1 | Silver halide photographic emulsions sensitized in the presence of organic disulfides and sulfinates | EASTMAN KODAK CO (US) | 1997-03-12 | — | — | EP | disclosed |
| US-5328820-A | Precipitation of silver halide, sensitization and adding antifogging agents | EASTMAN KODAK COMPANY (US) | 1994-07-12 | — | — | US | disclosed |
| EP-0599199-A1 | Silver halide photographic emulsions sensitized in the presence of organic disulfides and sulfinates | EASTMAN KODAK COMPANY (US) | 1994-06-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020107422-A1 | Process for producing allyl halide compound | ENY2, ZYX, RPS4Y1 | TSHR 3103/4885LMNA 2456/4885KMT2A 1123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.