Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.41 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GNRHR | P30968 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7512664 | 0.72 | SLC10A2 (0.43) | SMN1; SMN2GNRHRMAPK1TP53LMNA | |
| SCHEMBL7511306 | 0.69 | MAPT (0.38) | KDM4ESMN1; SMN2GNRHRMEN1KMT2A | |
| SCHEMBL8955489 | 0.67 | ADORA3 (0.63) | GAAKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL9388643 | 0.64 | BRD4 (0.47) | BRD4BRD2BRD3BRDTKDM4E | |
| SCHEMBL9387828 | 0.64 | BRD4 (0.44) | GAABRD4BRD2BRD3BRDT | |
| SCHEMBL2647704 | 0.63 | CACNA1F (0.56) | GAAKDM4ESMN1; SMN2PTPN1ADORA3 | |
| SCHEMBL10518334 | 0.63 | ACHE (0.43) | GAAKDM4ESMN1; SMN2PTPN1LMNA | |
| SCHEMBL7508121 | 0.62 | GAA (0.49) | GAAKDM4ESMN1; SMN2GNRHRMEN1 | |
| SCHEMBL9270856 | 0.62 | CACNA1D (0.45) | GAAKDM4ESMN1; SMN2ADORA3LMNA | |
| SCHEMBL8949608 | 0.62 | EPHX2 (0.51) | GAAKDM4ESMN1; SMN2ADORA3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608565-B1 | Pyridopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-03-13 | — | — | EP | disclosed |
| US-5654309-A | KIDNEY, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-08-05 | — | — | US | disclosed |