Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 0.67 |
| ▸ | MMP3 | P08254 | 2/20 | 0.67 |
| ▸ | MMP9 | P14780 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.59 |
| ▸ | THRB | P10828 | 3/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 5/20 | 0.56 |
| ▸ | MAOB | P27338 | 5/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.56 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | PARP1 | P09874 | 3/20 | 0.56 |
| ▸ | SLCO2B1 | O94956 | 3/20 | 0.56 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amentoflavone SCHEMBL7642601 | 0.90 | MEN1 (0.66) | APPMMP3MMP9KMT2AMEN1 | |
| Robustaflavone SCHEMBL561807 | 0.89 | APP (0.77) | APPMMP3MMP9KMT2AMEN1 | |
| Robustaflavone SCHEMBL7638211 | 0.88 | APP (0.76) | APPMMP3MMP9KMT2AMEN1 | |
| Robustaflavone SCHEMBL7643511 | 0.88 | APP (0.76) | APPMMP3MMP9KMT2AMEN1 | |
| Robustaflavone SCHEMBL624405 | 0.84 | APP (0.69) | APPMMP3MMP9KMT2AMEN1 | |
| SCHEMBL17166016 | 0.83 | APP (0.70) | APPMMP3MMP9KMT2AMEN1 | |
| Robustaflavone SCHEMBL7454193 | 0.81 | KMT2A (0.66) | APPMMP3MMP9KMT2AMEN1 | |
| SCHEMBL17166286 | 0.80 | APP (1.00) | APPMMP3MMP9KMT2AMEN1 | |
| Amentoflavone SCHEMBL29929632 | 0.78 | MEN1 (0.80) | APPMMP3MMP9KMT2AMEN1 | |
| Amentoflavone SCHEMBL312563 | 0.78 | MEN1 (0.80) | APPMMP3MMP9KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833631-B1 | ROBUSTAFLAVONE AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS | ADVANCED LIFE SCIENCES INC (US) | 2002-11-13 | — | — | EP | claimed |
| US-5773462-A | INFLUENZA THERAPY | MEDICHEM RESEARCH, INC. (US) | 1998-06-30 | — | — | US | claimed |