Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7520561 | 0.81 | HSP90AA1 (0.37) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL5157681 | 0.75 | LMNA (0.45) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL27565810 | 0.75 | HSP90AA1 (0.39) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL67859 | 0.72 | LMNA (0.58) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL8575083 | 0.71 | CA1 (0.47) | LMNASLC6A2HTR2BCYP1A2GABRA1 | |
| SCHEMBL8374271 | 0.69 | ALDH1A1 (0.31) | — | |
| SCHEMBL11144707 | 0.68 | LMNA (0.54) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL13773186 | 0.68 | LMNA (0.54) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL7516559 | 0.67 | CYP1A2 (0.39) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL19334576 | 0.66 | LMNA (0.44) | LMNATRPA1CHRM1SLC6A2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |