Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 9/20 | 0.44 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.44 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.43 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.43 |
| ▸ | ATIC | P31939 | 3/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29962321 | 0.82 | GART (0.46) | GARTSOSTMTHFD2MTHFD1ATIC | |
| Dihydrofolic Acid SCHEMBL7522026 | 0.81 | TYMS (0.66) | GARTSOSTMTHFD2MTHFD1ATIC | |
| Dihydrofolic Acid SCHEMBL12136386 | 0.81 | SOST (0.61) | GARTSOSTMTHFD2MTHFD1ATIC | |
| Dihydrofolic Acid SCHEMBL27589172 | 0.81 | SOST (0.61) | GARTSOSTMTHFD2MTHFD1ATIC | |
| Dihydrofolic Acid SCHEMBL8281 | 0.81 | SOST (0.61) | GARTSOSTMTHFD2MTHFD1ATIC | |
| Dihydrofolic Acid SCHEMBL8282 | 0.81 | SOST (0.61) | GARTSOSTMTHFD2MTHFD1ATIC | |
| Dihydrofolic Acid SCHEMBL27415499 | 0.80 | SOST (0.60) | GARTSOSTMTHFD2MTHFD1ATIC | |
| Dihydrofolic Acid SCHEMBL27779274 | 0.79 | SOST (0.60) | GARTSOSTMTHFD2MTHFD1ATIC | |
| SCHEMBL4616964 | 0.79 | MTHFD1 (0.47) | GARTSOSTMTHFD2MTHFD1ATIC | |
| SCHEMBL29619286 | 0.77 | TYMS (0.66) | GARTATICDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244789-A2 | GENES IDENTIFIED AS REQUIRED FOR PROLIFERATION OF E. COLI | Elitra Pharmaceuticals, Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2002010442-A1 | USE OF ECTOENZYMES AND SECRETED ENZYMES TO MONITOR CELLULAR PROLIFERATION | ELITRA PHARMACEUTICALS, INC. (US) | 2002-02-07 | — | — | WO | disclosed |
| EP-1149166-A2 | GENES IDENTIFIED AS REQUIRED FOR PROLIFERATION IN $i(ESCHERICHIA COLI) | Elitra Pharmaceuticals, Inc. (US) | 2001-10-31 | — | — | EP | disclosed |
| WO-2001048209-A2 | GENES IDENTIFIED AS REQUIRED FOR PROLIFERATION OF E. COLI | ELITRA PHARMACEUTICALS, INC. (US) | 2001-07-05 | — | — | WO | disclosed |
| WO-2001034810-A2 | GENES ESSENTIAL FOR MICROBIAL PROLIFERATION | ELITRA PHARMACEUTICALS, INC. (US) | 2001-05-17 | — | — | WO | disclosed |
| WO-2000044906-A2 | GENES IDENTIFIED AS REQUIRED FOR PROLIFERATION IN $i(ESCHERICHIA COLI) | ELITRA PHARMACEUTICALS, INC. (US) | 2000-08-03 | — | — | WO | disclosed |