Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH2 | P05091 | 1/20 | 0.41 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13950589 | 0.85 | MAOB (0.50) | ALDH2ALDH3A1MAOBKDM4ECYP1A2 | |
| SCHEMBL4290047 | 0.82 | MAOA (0.45) | MAOBFABP6 | |
| SCHEMBL28990338 | 0.82 | PARP10 (0.49) | MAOBHRH3PARP10 | |
| SCHEMBL32672830 | 0.77 | ALDH2 (0.41) | ALDH2ALDH3A1MAOBKDM4ECYP1A2 | |
| SCHEMBL3790824 | 0.77 | HTR2A (0.37) | KDM4ESRD5A1MLNRADRB2ADRB1 | |
| SCHEMBL28809160 | 0.77 | DRD2 (0.37) | SRD5A1MLNRADRB2ADRB1HTR1A | |
| SCHEMBL4596158 | 0.77 | AHR (0.43) | ALDH2ALDH3A1KDM4ECYP1A2GLA | |
| SCHEMBL5859179 | 0.77 | ALDH2 (0.41) | ALDH2ALDH3A1MAOBKDM4ECYP1A2 | |
| SCHEMBL3504905 | 0.77 | ALDH2 (0.47) | ALDH2ALDH3A1KDM4ECYP1A2GLA | |
| SCHEMBL30749724 | 0.77 | PTGS2 (0.51) | ALDH2ALDH3A1MAOBKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0111387-A1 | Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil | PFIZER INC. (US) | 1984-06-20 | — | — | EP | claimed |
| US-4431828-A | Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil | PFIZER INC. (US) | 1984-02-14 | — | — | US | claimed |
| EP-2220061-B1 | SPIRO-CONDENSED 1, 3, 4-THIADIAZOLE DERIVATIVES FOR INHIBITING KSP KINESIN ACTIVITY | MERCK SHARP & DOHME (US) | 2016-02-17 | — | — | EP | disclosed |
| US-8796460-B2 | Compounds for inhibiting KSP kinesin activity | Mercky Sharp & Dohme Corp. (US) | 2014-08-05 | — | — | US | disclosed |
| US-20120070370-A1 | SPIRO 1,3,4-THIADIAZOLINE DERIVATIVES AS KSP INHIBITORS | MERCK SHARP & DOHME CORP. | 2012-03-22 | — | — | US | disclosed |
| EP-2430030-A1 | SPIRO 1,3,4-THIADIAZOLINE DERIVATIVES AS KSP INHIBITORS | Schering Corporation (US) | 2012-03-21 | — | — | EP | disclosed |
| CN-102161653-A | Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor and uses thereof | ABBOTT LAB | 2011-08-24 | — | — | CN | disclosed |
| US-20110171172-A1 | COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY | MERCK SHARP & DOHME CORP. | 2011-07-14 | — | — | US | disclosed |
| US-20110123435-A1 | COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY | MERCK SHARP & DOHME LLC | 2011-05-26 | — | — | US | disclosed |
| WO-2010132520-A1 | SPIRO 1,3,4-THIADIAZOLINE DERIVATIVES AS KSP INHIBITORS | SCHERING CORPORATION (US) | 2010-11-18 | — | — | WO | disclosed |
| EP-2220061-A1 | SPIRO-CONDENSED 1, 3, 4-THIADIAZOLE DERIVATIVES FOR INHIBITING KSP KINESIN ACTIVITY | Schering Corporation (US) | 2010-08-25 | — | — | EP | disclosed |
| US-4740517-A | INHIBIT ALDOSE REDUCTASE | SANWA KAGAKU KENYUSHO CO., LTD. (JP) | 1988-04-26 | — | — | US | disclosed |
| CN-87100191-A | The hydroxy acid derivative of treatment diabetic complication | — | 1987-09-09 | — | — | CN | disclosed |
| EP-0193415-A2 | Spiro-3-heteroazolidine compounds and salts thereof, their preparation and pharmaceutical agents thereof | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1986-09-03 | — | — | EP | disclosed |
| EP-0185319-A2 | Fluoro coumarins as antilymphoedema agents | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1986-06-25 | — | — | EP | disclosed |
| US-4528387-A | Sorbinil by optical resolution of precursor 6-fluoro-4-ureidochroman-4-carboxylic acid | PFIZER INC. (US) | 1985-07-09 | — | — | US | disclosed |
| EP-0111387-A1 | Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil | PFIZER INC. (US) | 1984-06-20 | — | — | EP | disclosed |
| EP-0109231-A1 | Sorbinil by optical resolution with aminopinane derivatives | PFIZER INC. (US) | 1984-05-23 | — | — | EP | disclosed |
| US-4435578-A | Sorbinil by optical resolution of precursor 6-fluoro-4-ureidochroman-4-carboxylic acid | PFIZER INC. (US) | 1984-03-06 | — | — | US | disclosed |
| US-4431828-A | Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis of sorbinil | PFIZER INC. (US) | 1984-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120070370-A1 | SPIRO 1,3,4-THIADIAZOLINE DERIVATIVES AS KSP INHIBITORS | KIF2C, SKP1, KIF5B | ALDH2 1529/4885ALDH3A1 898/4885MAOB 3994/4885 |
| US-20110123435-A1 | COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY | KIF5B, KIF2C, KIFC1 | ALDH2 2621/4885ALDH3A1 2236/4885MAOB 3462/4885 |
| US-20110171172-A1 | COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY | KIF5B, KIF2C, KIFC1 | ALDH2 2315/4885ALDH3A1 1887/4885MAOB 3510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.