Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 5/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | SQLE | Q14534 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7523688 | 0.89 | VCAM1 (0.35) | MEN1KMT2ALMNAVCAM1MAPT | |
| SCHEMBL7524217 | 0.87 | VCAM1 (0.37) | KMT2ATSHRVCAM1MAPTSQLE | |
| SCHEMBL7518758 | 0.86 | VCAM1 (0.47) | VCAM1 | |
| SCHEMBL7523672 | 0.86 | BACE1 (0.39) | CYP3A4VCAM1MAPTSQLE | |
| SCHEMBL7520303 | 0.85 | VCAM1 (0.33) | VCAM1MAPTALDH1A1NR1H4 | |
| SCHEMBL8839727 | 0.85 | BACE1 (0.38) | CYP1A2CYP2C19VCAM1ALDH1A1HPGD | |
| SCHEMBL7513263 | 0.83 | CA2 (0.41) | MEN1KMT2ALMNACYP1A2CYP3A4 | |
| SCHEMBL7518926 | 0.83 | SLC6A9 (0.33) | MEN1KMT2ALMNACYP1A2CYP3A4 | |
| SCHEMBL7522609 | 0.82 | CALM1 (0.33) | MEN1KMT2AVCAM1MAPTALDH1A1 | |
| SCHEMBL8517276 | 0.79 | ADORA3 (0.35) | MEN1KMT2ALMNAMAPTSQLE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |