Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 7/20 | 0.33 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7522609 | 0.84 | CALM1 (0.33) | MAPTCALM1ALDH1A1HPGDMEN1 | |
| SCHEMBL7517843 | 0.82 | CALM1 (0.36) | MAPTCALM1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL27566673 | 0.75 | KMT2A (0.37) | AKT1MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7521009 | 0.73 | VCAM1 (0.37) | CALM1KMT2AGAA | |
| SCHEMBL7517609 | 0.70 | VCAM1 (0.45) | MAPTCALM1ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL27852474 | 0.69 | AKT1 (0.46) | AKT1MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7523700 | 0.69 | NR1H4 (0.35) | MEN1KMT2AGAA | |
| SCHEMBL7526592 | 0.68 | MEN1 (0.32) | MAPTALDH1A1HPGDCYP2C19MEN1 | |
| SCHEMBL7516554 | 0.68 | GAA (0.34) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL7506473 | 0.65 | AKT1 (0.47) | AKT1MAPTALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |