Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.69 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | AKT2 | P31751 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL738518 | 0.83 | OPRM1 (1.00) | OPRM1HTR2AAKT2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1765284 | 0.81 | OPRM1 (0.95) | OPRM1HTR2AAKT2MEN1KMT2A | |
| SCHEMBL23647413 | 0.77 | OPRM1 (0.41) | OPRM1MEN1KMT2AALDH1A1CHRNB2 | |
| SCHEMBL639774 | 0.77 | ALDH1A1 (0.51) | OPRM1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL31158371 | 0.77 | OPRM1 (0.41) | OPRM1MEN1KMT2AALDH1A1CHRNB2 | |
| SCHEMBL13139599 | 0.77 | OPRM1 (0.41) | OPRM1HTR2AMEN1KMT2AALDH1A1 | |
| SCHEMBL30814823 | 0.77 | ALDH1A1 (0.51) | OPRM1MEN1KMT2AALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL20744334 | 0.76 | OPRM1 (0.40) | OPRM1HTR2AMEN1KMT2AALDH1A1 | |
| SCHEMBL7885473 | 0.76 | OPRM1 (0.83) | OPRM1HTR2AAKT2MEN1KMT2A | |
| SCHEMBL8302463 | 0.76 | ITGA4 (0.46) | OPRM1MEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020010186-A1 | Dihydropyrimidines and uses thereof | SYNAPTIC PHARMACEUTICAL CORPORATION | 2002-01-24 | — | — | US | disclosed |
| US-6245773-B1 | BENIGN PROSTATIC HYPERPLAMIA; REDUCTION OF INTRAOCULAR PRESSURE | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-06-12 | — | — | US | disclosed |
| WO-1998051311-A2 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020010186-A1 | Dihydropyrimidines and uses thereof | QDPR, DPYD, ADRA1D | OPRM1 878/4885HTR2A 590/4885AKT2 3253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.