Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7522579 | 0.82 | MEN1 (0.47) | MEN1KMT2AHPGDALDH1A1RECQL | |
| SCHEMBL8978583 | 0.76 | NPC1 (0.35) | NPC1RAB9AMEN1KMT2AHPGD | |
| SCHEMBL5543986 | 0.74 | GPR84 (0.33) | MEN1KMT2ARECQLGPR84 | |
| SCHEMBL14437373 | 0.73 | MEN1 (0.32) | MEN1KMT2ARECQLGPR84 | |
| SCHEMBL7525130 | 0.71 | GPR84 (0.58) | NPC1RAB9AMEN1KMT2AHPGD | |
| SCHEMBL7530261 | 0.71 | GPR84 (0.43) | ATMMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL9185542 | 0.70 | HSD17B10 (0.33) | NPC1RAB9AMAPTPOLB | |
| SCHEMBL10102260 | 0.69 | GPR84 (0.34) | GPR84 | |
| SCHEMBL1699832 | 0.67 | ALDH1A1 (0.34) | NPC1MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL14267935 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020173667-A1 | NOVEL AROMATIC SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL LIMITED (IE) | 2002-11-21 | — | — | US | claimed |
| US-6478989-B1 | Aromatic substituted naphthopyrans | TRANSITIONS OPTICAL, INC. | 2002-11-12 | — | — | US | claimed |
| EP-1017690-B1 | NOVEL AROMATIC SUBSTITUTED NAPHTHOPYRANS | PPG IND OHIO INC (US) | 2001-12-05 | — | — | EP | claimed |
| US-20020173667-A1 | NOVEL AROMATIC SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL LIMITED (IE) | 2002-11-21 | — | — | US | disclosed |
| US-6478989-B1 | Aromatic substituted naphthopyrans | TRANSITIONS OPTICAL, INC. | 2002-11-12 | — | — | US | disclosed |
| EP-1017690-B1 | NOVEL AROMATIC SUBSTITUTED NAPHTHOPYRANS | PPG IND OHIO INC (US) | 2001-12-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020173667-A1 | NOVEL AROMATIC SUBSTITUTED NAPHTHOPYRANS | TYR, B3GNT2, PAH | MAOB 656/4885NPC1 1219/4885RAB9A 3013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.