Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26290022 | 0.88 | KDM4E (0.45) | GPR84SLC6A3SLC6A4SLC6A2ALDH1A1 | |
| SCHEMBL26289989 | 0.86 | GPR84 (0.38) | GPR84SLC6A3SLC6A4SLC6A2ALDH1A1 | |
| SCHEMBL7525130 | 0.85 | GPR84 (0.58) | GPR84ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL9912591 | 0.81 | ALDH1A1 (0.39) | GPR84ALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL7777302 | 0.79 | DHODH (0.37) | GPR84ALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL6131938 | 0.78 | DHODH (0.40) | ALDH1A1KDM4EHPGDNPSR1MEN1 | |
| SCHEMBL5107478 | 0.78 | NR4A2 (0.37) | GPR84ALDH1A1KDM4EHPGDNPSR1 | |
| SCHEMBL13868624 | 0.78 | KDM4E (0.35) | GPR84SLC6A3SLC6A4SLC6A2ALDH1A1 | |
| SCHEMBL26290020 | 0.77 | GPR35 (0.40) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL4798246 | 0.77 | PLA2G2A (0.41) | ALDH1A1KDM4EHPGDNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020173667-A1 | NOVEL AROMATIC SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL LIMITED (IE) | 2002-11-21 | — | — | US | claimed |
| US-6478989-B1 | Aromatic substituted naphthopyrans | TRANSITIONS OPTICAL, INC. | 2002-11-12 | — | — | US | claimed |
| EP-1017690-B1 | NOVEL AROMATIC SUBSTITUTED NAPHTHOPYRANS | PPG IND OHIO INC (US) | 2001-12-05 | — | — | EP | claimed |
| US-20020173667-A1 | NOVEL AROMATIC SUBSTITUTED NAPHTHOPYRANS | TRANSITIONS OPTICAL LIMITED (IE) | 2002-11-21 | — | — | US | disclosed |
| US-6478989-B1 | Aromatic substituted naphthopyrans | TRANSITIONS OPTICAL, INC. | 2002-11-12 | — | — | US | disclosed |
| EP-1017690-B1 | NOVEL AROMATIC SUBSTITUTED NAPHTHOPYRANS | PPG IND OHIO INC (US) | 2001-12-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020173667-A1 | NOVEL AROMATIC SUBSTITUTED NAPHTHOPYRANS | TYR, B3GNT2, PAH | GPR84 3665/4885SLC6A3 3085/4885SLC6A4 2463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.