Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.62 |
| ▸ | IDO1 | P14902 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 9/20 | 0.56 |
| ▸ | RAB9A | P51151 | 9/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31298914 | 0.88 | HPGD (0.55) | MTNR1AMTNR1BIDO1NPC1RAB9A | |
| SCHEMBL3716262 | 0.87 | IDO1 (0.47) | MTNR1AMTNR1BIDO1NPC1RAB9A | |
| SCHEMBL7894530 | 0.87 | MTNR1A (0.48) | MTNR1AMTNR1BIDO1HPGDALDH1A1 | |
| SCHEMBL17548578 | 0.85 | IDO1 (0.51) | MTNR1AMTNR1BIDO1NPC1RAB9A | |
| SCHEMBL22015112 | 0.85 | ALDH1A1 (0.53) | MTNR1AMTNR1BIDO1NPC1RAB9A | |
| SCHEMBL24671054 | 0.85 | IDO1 (0.49) | MTNR1AMTNR1BIDO1NPC1RAB9A | |
| SCHEMBL10493769 | 0.85 | IDO1 (0.46) | MTNR1AMTNR1BIDO1NPC1RAB9A | |
| SCHEMBL4612706 | 0.85 | IDO1 (0.46) | MTNR1AMTNR1BIDO1NPC1RAB9A | |
| SCHEMBL18295921 | 0.85 | L3MBTL1 (0.55) | MTNR1AMTNR1BIDO1NPC1RAB9A | |
| SCHEMBL8771970 | 0.84 | MTNR1A (0.51) | MTNR1AMTNR1BNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380228-B1 | E.G., N-(2-PHENYLSULFONYL-1-ETHYL)-3-(4-CYANOPHENYL)-2,3-DIHYDRO-IMIDAZO(2,1 -B)THIAZOLE-5-CARBOXAMIDE HYDROCHLORIDE; TREATING CANCER, NEUROFIBROMIN BENIGN PROLIFERATIVE DISORDER, RETINAL VASCULARIZATION, AND HEPATITIS DELTA | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| US-20020045759-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. | 2002-04-18 | — | — | US | disclosed |
| WO-2001076694-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020045759-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | FNTA, KRAS, PTAR1 | MTNR1A 4022/4885MTNR1B 4190/4885IDO1 4282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.