Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 6/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 5/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7529171 | 0.84 | DAGLA (0.40) | KMT2AMMEACE | |
| SCHEMBL7529175 | 0.81 | PSMB5 (0.42) | KMT2AANPEPPSMB5PSMB8CHRNB2 | |
| SCHEMBL6463671 | 0.80 | REN (0.47) | ANPEPPRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL7529181 | 0.78 | EPHX2 (0.40) | KMT2AANPEPPSMB5TBXA2RCYP2C9 | |
| SCHEMBL6063863 | 0.76 | NFKB1 (0.41) | ANPEPPSMB5NFKB1NFKB2RELA | |
| SCHEMBL6062848 | 0.75 | DAGLA (0.39) | KMT2A | |
| SCHEMBL6063868 | 0.73 | PSMB5 (0.44) | ANPEPPSMB5NFKB1NFKB2RELA | |
| SCHEMBL6475526 | 0.73 | FAAH (0.46) | CYP2C9 | |
| SCHEMBL6463220 | 0.71 | CTSL (0.51) | — | |
| SCHEMBL6464784 | 0.70 | ANPEP (0.48) | ANPEPPSMB5TBXA2RNFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161422-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055144-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |