Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 8/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6063695 | 0.84 | DAGLA (0.38) | PSMB5MMP8ALDH1A1CTSLCTSB | |
| SCHEMBL6063868 | 0.82 | PSMB5 (0.44) | NFKB1PSMB5NFKB2RELAMMP8 | |
| SCHEMBL6463220 | 0.82 | CTSL (0.51) | MMP3CTSLCTSBCTSSCTSK | |
| SCHEMBL6464784 | 0.79 | ANPEP (0.48) | NFKB1PSMB5NFKB2RELAMMP8 | |
| SCHEMBL6477967 | 0.78 | MMP3 (0.44) | MMP8ANPEPMMP3CTSLCTSB | |
| SCHEMBL6466269 | 0.78 | MMP9 (0.44) | NFKB1PSMB5NFKB2RELAMMP8 | |
| SCHEMBL6466271 | 0.78 | MMP9 (0.44) | NFKB1PSMB5NFKB2RELAMMP8 | |
| SCHEMBL6464783 | 0.78 | MMP9 (0.44) | NFKB1PSMB5NFKB2RELAMMP8 | |
| SCHEMBL6463671 | 0.76 | REN (0.47) | ALDH1A1ANPEPMMP3CTSLCTSB | |
| SCHEMBL7529166 | 0.76 | KMT2A (0.42) | NFKB1PSMB5NFKB2RELAANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694357-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058348-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-30 | — | — | WO | disclosed |