Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7529166 | 0.78 | KMT2A (0.42) | KMT2AANPEPCYP2C9TBXA2RPSMB5 | |
| SCHEMBL6463671 | 0.73 | REN (0.47) | ANPEPCYP2C9CYP2C19 | |
| SCHEMBL7529175 | 0.72 | PSMB5 (0.42) | KMT2AANPEPCYP2C9TBXA2RPSMB5 | |
| SCHEMBL6063863 | 0.70 | NFKB1 (0.41) | MMP8ANPEPPSMB5 | |
| SCHEMBL6477967 | 0.70 | MMP3 (0.44) | KMT2AMMP8ANPEPCYP2D6CYP2C9 | |
| SCHEMBL6063167 | 0.67 | CTSL (0.51) | — | |
| SCHEMBL6063868 | 0.64 | PSMB5 (0.44) | MMP8ANPEPCYP2D6CYP2C19PSMB5 | |
| SCHEMBL7558531 | 0.63 | DAGLA (0.39) | KMT2AFAAHCYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6467199 | 0.62 | DAGLA (0.41) | EPHX2TBXA2RDAGLA | |
| SCHEMBL17749487 | 0.62 | CHRNB2 (0.51) | KMT2AMTNR1ACYP2C9HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161422-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055144-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |